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Product Description
Mechanism of Action
is a researchgrade compound that demonstrates a multilayered biochemical activity profile. Its effects arise through coordinated modulation of enzymatic cascades, highaffinity receptor binding, posttranslational regulation and structural interactions with intracellular effector molecules. At the cellular level, the compound influences phosphorylationdephosphorylation cycles, alters mitochondrial bioenergetics, rebalances oxidative stress pathways, and modulates calciumdependent signalling nodes. Its mechanistic footprint extends into transcriptional regulatory networks, where it can affect chromatin accessibility, gene expression stability, and the activation threshold of stressresponse transcription factors.
Depending on concentration, exposure duration and cellular phenotype, the compound may act as a signal amplifier, a selective inhibitor of metabolic bottlenecks, or a regulatory dampener for hyperactive pathways. Its physiochemical structure suggests steric complementarity to enzyme pockets, with likely engagement of hydrogenbond networks and hydrophobic stabilization forces influencing downstream activity.
Benefits and Advantages
This compound offers broad utility across biochemical, cellular and preclinical research domains. Its reproducible mechanistic behaviour makes it suitable for:
- Pathway validation in kinase and phosphatasedependent systems
- Receptor activation/inhibition experiments in endocrine, metabolic and immunologic models
- Multiomics profiling, including transcriptomics, metabolomics and proteomics
- Stressresponse modelling involving ROS balance, mitochondrial function and cellular resilience mechanisms
- Highresolution SAR (structureactivity relationship) investigations
- Pharmacodynamic simulation studies for doseresponse optimisation
Because of its predictable biochemical footprint, the compound is frequently used as a reference standard for assessing new molecular candidates, benchmarking pathway perturbation sensitivity and calibrating screening platforms.
Side Effects and Risks
Observed or theoretically predicted risks include mitochondrial overload, disruption of redox homeostasis, membrane-integrity perturbation and unscheduled apoptosis or autophagy induction at high doses. Offtarget receptor binding may modify unintended signalling axes such as MAPK, JNK, NF-κB or PI3K/AKT pathways. Chronic or excessive exposure may influence calcium flux, impair proteostasis, or interfere with cytoskeletal dynamics.
Use of the compound should be limited to controlled laboratory environments with appropriate biosafety measures, including dose titration, controlled handling procedures and protective containment. It is not intended for human or veterinary use.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C153H225N43O49S |
|---|---|
| Molecular Weight | 3482.7 g/mol |
| CAS Number | 9007-92-5 |
| Storage Condition | Glucagon powder for injection should be stored at 15-30 degrees C. … Solutions of the drug are stable … when stored at 5 degrees C. |
| Solubility | SOL IN DIL ALKALI & ACID SOLN; INSOL IN MOST ORG SOLVENTS |
| Purity | Purity information is available upon request (COA). |
| Synonym | GLUCAGON; Glucagonum; Glucagone; Glukagon Novo; Glucagon, pig |
| IUPAC/Chemical Name | (3S)-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid |
| InChl Key | MASNOZXLGMXCHN-ZLPAWPGGSA-N |
| InChl Code | InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 |
| References |
3D Conformer.
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