About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Gefitinib is a selective EGFR tyrosine-kinase inhibitor that blocks ATP binding to the intracellular kinase domain, inhibiting signalling pathways involved in tumor growth, proliferation and survival.
Benefits and Advantages
Used in EGFR-signalling research, oncogenic mutation modelling, kinase-inhibition assays and cancer therapeutics screening.
Side Effects and Risks
Rash, diarrhea, hepatotoxicity and interstitial lung disease. Handle with cytotoxic-kinase inhibitor precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H24ClFN4O3 |
|---|---|
| Molecular Weight | 446.9 g/mol |
| CAS Number | 184475-35-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Sparingly soluble (<pH4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Gefitinib; 184475-35-2; Iressa; ZD1839; Irressat |
| IUPAC/Chemical Name | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine |
| InChl Key | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) |
| References |
3D Conformer.
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