FULVESTRANT
Fulvestrant is an estrogen receptor antagonist used in hormone‑positive breast cancer. Side effects include injection‑site pain, nausea, and fatigue.
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Product Description
Mechanism of Action
Fulvestrant is a selective estrogen receptor degrader (SERD) that binds ERα, accelerates receptor degradation and blocks estrogen‑mediated transcription.
Benefits and Advantages
Used in endocrine‑therapy models, ER degradation assays, breast‑cancer signalling research and SERD SAR analysis.
Side Effects and Risks
Injection‑site pain, hot flashes, nausea and hepatic changes.
Datasheet
| Molecular Formula | C32H47F5O3S |
|---|---|
| Molecular Weight | 606.8 g/mol |
| CAS Number | 129453-61-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Fulvestrant; 129453-61-8; Faslodex; Ici 182780; ICI-182780 |
| IUPAC/Chemical Name | (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
| InChl Key | VWUXBMIQPBEWFH-WCCTWKNTSA-N |
| InChl Code | InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1 |
| References |
3D Conformer.
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