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Product Description
Mechanism of Action
Etidronate disodium is a first‑generation bisphosphonate that binds strongly to hydroxyapatite in bone. It inhibits osteoclast‑mediated bone resorption by interfering with ATP‑dependent intracellular pathways and inducing osteoclast apoptosis. Because etidronate also affects mineralization at high doses, it has dual actions on bone turnover and calcification.
Benefits and Advantages
Used in bone‑remodelling pathway studies, hydroxyapatite‑binding research, osteoclast inhibition assays, and metabolic‑bone‑disease modelling.
Side Effects and Risks
Risks include hypocalcemia, osteomalacia (high doses), GI irritation, and rare atypical calcification disturbances. Handle with bisphosphonate‑class precautions.
Datasheet
| Molecular Formula | C2H6Na2O7P2 |
|---|---|
| Molecular Weight | 249.99 g/mol |
| CAS Number | 7414-83-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 1.15e+01 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | Etidronate disodium; 7414-83-7; Disodium etidronate; Sodium etidronate; Disodium ethydronate |
| IUPAC/Chemical Name | disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate |
| InChl Key | GWBBVOVXJZATQQ-UHFFFAOYSA-L |
| InChl Code | InChI=1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2 |
| References |
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