About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Erlotinib is a selective smallmolecule inhibitor of EGFR (ErbB1) tyrosine kinase. It binds the ATPbinding site of EGFR, blocking autophosphorylation and downstream signalling across the RASRAFMEKERK and PI3KAKT pathways. It is particularly effective in EGFRactivating mutation models.
Benefits and Advantages
Used in EGFRpathway research, kinaseinhibition profiling, oncogenedriven tumour modelling, and resistancemutation evolution assays.
Side Effects and Risks
Risks include rash, diarrhea, hepatotoxicity, interstitial lung disease (rare) and photosensitivity. Handle with EGFRinhibitor precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H23N3O4 |
|---|---|
| Molecular Weight | 393.4 g/mol |
| CAS Number | 183321-74-6 |
| Storage Condition | Store at 25 °C (77 °F); excursions permitted to 15 – 30 °C (59 – 86 °F). |
| Solubility | Very slightly soluble (hydrochloride salt – maximal solubility of approximately 0.4 mg/mL occurs at a pH of approximately 2) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Erlotinib; 183321-74-6; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-; erlotinibum |
| IUPAC/Chemical Name | N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine |
| InChl Key | AAKJLRGGTJKAMG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) |
| References |
3D Conformer.
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