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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Efavirenz is a non‑nucleoside reverse transcriptase inhibitor (NNRTI) that binds an allosteric pocket on HIV‑1 reverse transcriptase. This induces conformational changes that block polymerase activity, inhibiting viral DNA synthesis. It displays potent antiviral activity but has CNS‑penetrant effects due to high lipophilicity.
Benefits and Advantages
Used in NNRTI‑mechanism studies, HIV‑polymerase allosteric‑inhibition assays, resistance‑mutation modelling, and antiviral‑SAR research.
Side Effects and Risks
Risks include CNS effects (vivid dreams, dizziness), hepatotoxicity, rash, psychiatric symptoms and teratogenicity risk. Handle with antiviral‑compound precautions.
Datasheet
| Molecular Formula | C14H9ClF3NO2 |
|---|---|
| Molecular Weight | 315.67 g/mol |
| CAS Number | 154598-52-4 |
| Storage Condition | Commercially available efavirenz capsules and tablets should be stored at a controlled room temperature of 25 °C, but may be exposed to temperatures ranging from 15-30 °C. |
| Solubility | Practically insoluble in water (less than 10 mg/L) |
| Purity | Purity information is available upon request (COA). |
| Synonym | efavirenz; 154598-52-4; Sustiva; Stocrin; DMP-266 |
| IUPAC/Chemical Name | (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one |
| InChl Key | XPOQHMRABVBWPR-ZDUSSCGKSA-N |
| InChl Code | InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 |
| References |
3D Conformer.
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