About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dirocaftor (VX561) is a nextgeneration CFTR potentiator designed to enhance the gating function of mutant CFTR channels at the cell surface. By increasing the open probability of CFTR, it improves chloride transport across epithelial membranes in cystic fibrosis models with specific gating mutations.
Benefits and Advantages
Used in CFTRmodulator research, ionchannel pharmacology studies, epithelialtransport modelling, combinationtherapy investigations with CFTR correctors, and precisionmedicine development for cystic fibrosis.
Side Effects and Risks
Risks (based on class effects) may include hepatic enzyme elevations, GI symptoms, headache and respiratory events; longterm safety is evaluated in controlled models. Handle as a targeted ionchannel modulator.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H28N2O3Si2 |
|---|---|
| Molecular Weight | 424.6 g/mol |
| CAS Number | 2137932-23-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Dirocaftor; Dirocaftor [USAN]; PTI-808; 2137932-23-9; 2G3T6M1AS9 |
| IUPAC/Chemical Name | N-[5-hydroxy-2,4-bis(trimethylsilyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide |
| InChl Key | TYQIFWXBQYAKCR-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H28N2O3Si2/c1-28(2,3)19-12-20(29(4,5)6)18(25)11-17(19)24-22(27)15-13-23-16-10-8-7-9-14(16)21(15)26/h7-13,25H,1-6H3,(H,23,26)(H,24,27) |
| References |
3D Conformer.
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