DIIODOTYROSINE
Diiodotyrosine is a thyroid hormone precursor formed during iodination of tyrosine residues on thyroglobulin. Benefits include its role in T3/T4 synthesis. Side effects are linked to excess iodine exposure, including thyroid dysfunction or hypersensitivity. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Diiodotyrosine (DIT) is an iodinated tyrosine derivative and a key intermediate in thyroid hormone synthesis. Thyroid peroxidase catalyzes iodination of tyrosine residues on thyroglobulin, and coupling of two DIT units produces thyroxine (T). DIT participates in oxidative, peroxidasedependent pathways critical to endocrine physiology.
Benefits and Advantages
Used in thyroidhormone biosynthesis studies, halogenationpathway modelling, peroxidaseenzyme assays, and endocrinemetabolism research.
Side Effects and Risks
Risks include iodinerelated hypersensitivity, interference with thyroid assays, and oxidative reactivity. Handle with iodinatedaminoacid precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C9H9I2NO3 |
|---|---|
| Molecular Weight | 432.98 g/mol |
| CAS Number | 300-39-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 0.617 mg/mL at 25 °C |
| Purity | Purity information is available upon request (COA). |
| Synonym | 3,5-Diiodo-L-tyrosine; 300-39-0; L-3,5-Diiodotyrosine; L-Diiodotyrosine; (2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid |
| IUPAC/Chemical Name | (2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid |
| InChl Key | NYPYHUZRZVSYKL-ZETCQYMHSA-N |
| InChl Code | InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1 |
| References |
3D Conformer.
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