DIIODOHYDROXYQUINOLINE
Diiodohydroxyquinoline is an antiamoebic agent acting locally in the intestine by interfering with protozoal metabolism. It is used for asymptomatic amoebiasis. Side effects may include nausea, abdominal discomfort, and rare neurotoxicity with prolonged use. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Diiodohydroxyquinoline is a halogenated 8hydroxyquinoline derivative with amoebicidal activity. Its mechanism involves metalchelating interactions and disruption of protozoal enzyme systems, particularly in the intestinal lumen. The iodine substitution enhances lipophilicity, aiding local antiparasitic action without significant systemic absorption.
Benefits and Advantages
Used in amoebiasismodelling studies, metalchelation research, parasiticenzyme inhibition assays, and luminal antiparasitic drugdevelopment work.
Side Effects and Risks
Risks include iodine sensitivity, gastrointestinal irritation, neurotoxicity at extremely high exposures, and alteration of gut flora. Handle with halogenatedquinoline precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C9H5I2NO |
|---|---|
| Molecular Weight | 396.95 g/mol |
| CAS Number | 83-73-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | ALMOST INSOL IN WATER; SPARINGLY SOL IN ALCOHOL, ETHER, ACETONE; SOL IN HOT PYRIDINE & HOT DIOXANE |
| Purity | Purity information is available upon request (COA). |
| Synonym | iodoquinol; 83-73-8; Diiodohydroxyquinoline; 5,7-diiodoquinolin-8-ol; 5,7-Diiodo-8-hydroxyquinoline |
| IUPAC/Chemical Name | 5,7-diiodoquinolin-8-ol |
| InChl Key | UXZFQZANDVDGMM-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H |
| References |
3D Conformer.
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