DESMETHYLCLOZAPINE
Desmethylclozapine is an active metabolite of clozapine with partial agonist activity at muscarinic and dopaminergic receptors, contributing to therapeutic and adverse effects. Side effects include sedation, tachycardia, and metabolic changes. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Desmethylclozapine (norclozapine) is the major active metabolite of clozapine with unique pharmacologic properties. It acts as a partial agonist at muscarinic M receptors, modulates dopaminergic and serotonergic pathways, and contributes significantly to clozapines clinical and mechanistic profile.
Benefits and Advantages
Used in atypicalantipsychotic research, Mreceptor pathway studies, dopaminergic/serotonergic modelling, metaboliteactivity assays and CNS drugmechanism investigations.
Side Effects and Risks
Risks include seizures, agranulocytosis (rare), metabolic disturbances, sedation and cholinergic effects. Handle with CNSactive antipsychoticcompound precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C17H17ClN4 |
|---|---|
| Molecular Weight | 312.8 g/mol |
| CAS Number | 6104-71-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | N-Desmethylclozapine; Norclozapine; 6104-71-8; Desmethylclozapine; NDMC |
| IUPAC/Chemical Name | 3-chloro-6-piperazin-1-yl-11H-benzo[b][1,4]benzodiazepine |
| InChl Key | JNNOSTQEZICQQP-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
