DESLORATADINE
Desloratadine is a selective, nonsedating antihistamine blocking H1 receptors to treat allergic rhinitis and urticaria. Benefits include long-lasting relief with minimal drowsiness. Side effects include headache, dry mouth, and fatigue. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Desloratadine is a longacting, selective Hreceptor antagonist that blocks histaminemediated vasodilation, vascular permeability and sensorynerve activation. It exhibits minimal CNS penetration and limited sedation due to high Pgp efflux at the bloodbrain barrier.
Benefits and Advantages
Used in allergymodelling research, Hantagonist SAR studies, inflammatorymediator assays, and mastcell mediator pathway analysis.
Side Effects and Risks
Risks include headache, dry mouth, fatigue, rare cardiac arrhythmias and hypersensitivity reactions. Handle as a lowsedation antihistamine.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C19H19ClN2 |
|---|---|
| Molecular Weight | 310.8 g/mol |
| CAS Number | 100643-71-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 3.95e-03 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | Desloratadine; 100643-71-8; Clarinex; Descarboethoxyloratadine; Desloratidine |
| IUPAC/Chemical Name | 13-chloro-2-piperidin-4-ylidene-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene |
| InChl Key | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 |
| References |
3D Conformer.
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