DAPRODUSTAT
Daprodustat is an oral HIF‑prolyl hydroxylase inhibitor that stimulates endogenous erythropoietin production and enhances iron utilization. It is used to treat anemia in chronic kidney disease. Benefits include an oral alternative to injectable ESAs and stable hemoglobin control. Side effects include hypertension, thromboembolic risk, and gastrointestinal symptoms.
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Product Description
Mechanism of Action
Daprodustat is a hypoxia‑inducible factor prolyl hydroxylase inhibitor (HIF‑PHI). By inhibiting HIF‑PHD enzymes, it stabilizes HIF‑α, promoting transcription of erythropoietic genes including EPO and iron‑handling proteins. This stimulates endogenous red‑blood‑cell production.
Benefits and Advantages
Used in anemia‑research models, hypoxia‑signalling studies, HIF‑pathway analysis, iron‑metabolism assays and erythropoiesis‑modelling research.
Side Effects and Risks
Risks include hypertension, thrombotic events, neoplasia concerns, hyperkalemia and GI symptoms. Handle as a potent HIF‑pathway modulator.
Datasheet
| Molecular Formula | C19H27N3O6 |
|---|---|
| Molecular Weight | 393.4 g/mol |
| CAS Number | 960539-70-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Daprodustat; 960539-70-2; GSK1278863; GSK-1278863; JESDUVROQ |
| IUPAC/Chemical Name | 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid |
| InChl Key | RUEYEZADQJCKGV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24) |
| References |
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