CYTIDINE

Cytarabine (ara‑C) is a DNA polymerase inhibitor used in leukemia. Side effects include myelosuppression, rash, and neurotoxicity at high doses.

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Product Description


Mechanism of Action

Cytidine is a pyrimidine nucleoside composed of cytosine linked to a ribose sugar. It serves as a fundamental building block of RNA and a precursor for cytidine triphosphate (CTP), which participates in phospholipid synthesis and RNA polymerization. Cytidine and its deoxy forms are also central to epigenetic regulation via cytosine methylation and demethylation cycles.

Benefits and Advantages

Used in nucleotide‑metabolism research, RNA‑synthesis studies, phospholipid‑biosynthesis modelling, epigenetic‑pathway analyses, and nucleoside‑transport investigations. It is also used as a reference substrate in kinase and deaminase enzyme assays.

Side Effects and Risks

Risks include minimal toxicity at research doses, but high concentrations may disrupt nucleotide balance and cellular metabolism. Handle as a low‑hazard biochemical with standard lab precautions.

Datasheet


Molecular Formula

C9H13N3O5

Molecular Weight

243.22 g/mol

CAS Number

65-46-3

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)

Purity

Purity information is available upon request (COA).

Synonym

cytidine; 65-46-3; Cytosine riboside; 1-beta-D-Ribofuranosylcytosine; 4-Amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone

IUPAC/Chemical Name

4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChl Key

UHDGCWIWMRVCDJ-XVFCMESISA-N

InChl Code

InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1

References

https://pubchem.ncbi.nlm.nih.gov/compound/6175;

3D Conformer.

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