About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Clofazimine is a riminophenazine antimicrobial with antimycobacterial and antiinflammatory properties. It intercalates into bacterial DNA, disrupts replication and induces reactive oxygen species through redox cycling. Its antiinflammatory benefits derive from inhibition of neutrophil chemotaxis.
Benefits and Advantages
Used in mycobacterialdisease research (e.g., *M. leprae*, *M. abscessus*), intracellularpathogen modelling, redoxsignalling studies, hostimmune modulation experiments and macrophagepharmacology research.
Side Effects and Risks
Risks include redbrown skin discoloration, GI discomfort, hepatic dysfunction, QT prolongation and deposition in fatty tissues. Handle with pigmentingdrug precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C27H22Cl2N4 |
|---|---|
| Molecular Weight | 473.4 g/mol |
| CAS Number | 2030-63-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | clofazimine; 2030-63-9; Lamprene; Chlofazimine; Clofazimina |
| IUPAC/Chemical Name | N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine |
| InChl Key | WDQPAMHFFCXSNU-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3 |
| References |
3D Conformer.
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