About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Clinafloxacin is a potent fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV, causing irreversible DNA damage. It exhibits strong activity against gram‑negative bacteria, gram‑positive cocci and anaerobes, including some drug‑resistant strains. Its unique C‑8 substituent enhances potency but is associated with phototoxicity.
Benefits and Advantages
Used in resistant‑pathogen modelling, anaerobic‑susceptibility studies, quinolone SAR research, DNA‑damage pathway studies and broad‑spectrum PK/PD modelling.
Side Effects and Risks
Risks include severe phototoxicity, dysglycemia, CNS effects, QT prolongation and tendon toxicity. Handle with enhanced fluoroquinolone safety measures.
Datasheet
| Molecular Formula | C22H21ClFN3O3 |
|---|---|
| Molecular Weight | 365.8 g/mol |
| CAS Number | 105956-97-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >54.9 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | CLINAFLOXACIN; 105956-97-6; CI-960; clinafloxacine; clinafloxacino |
| IUPAC/Chemical Name | 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid |
| InChl Key | QGPKADBNRMWEQR-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25) |
| References |
3D Conformer.
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