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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cilastatin sodium is a dehydropeptidaseI (DHP1) inhibitor that prevents renal breakdown of imipenem. It binds the active site of DHP1 on proximal tubular brushborder membranes, blocking enzymatic hydrolysis of the lactam ring. This increases imipenem halflife and prevents formation of nephrotoxic metabolites.
Benefits and Advantages
Used in lactam stability research, renalenzyme inhibition studies, PK/PD modelling of carbapenems, combinationtherapy optimisation and nephrotoxicityprevention research. Essential in studying kidney enzymedrug interactions.
Side Effects and Risks
Risks include GI upset, headache, hepatic enzyme elevation and rare hypersensitivity reactions. Handle with enzymeinhibitor precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C16H23N2NaO5S |
|---|---|
| Molecular Weight | 380.4 g/mol |
| CAS Number | 81129-83-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 1.00e-01 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | Cilastatin sodium; 81129-83-1; Cilastatin sodium salt; DTXSID2046915; DTXCID0026915 |
| IUPAC/Chemical Name | sodium (Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate |
| InChl Key | QXPBTTUOVWMPJN-QBNHLFMHSA-M |
| InChl Code | InChI=1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1 |
| References | PubChem; ChemBL; FDA; |
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