About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Chlorpromazine hydrochloride is a phenothiazine antipsychotic and dopamine D₂ receptor antagonist. It also blocks H₁ histamine receptors, α₁-adrenergic receptors, muscarinic receptors and serotonin receptors, producing broad CNS effects. D₂ antagonism in the mesolimbic pathway reduces psychotic symptoms, while widespread receptor blockade contributes to sedation, hypotension and anticholinergic effects.
Benefits and Advantages
Used in dopamine-pathway research, schizophrenia-modelling studies, antiemetic mechanism studies, behavioural pharmacology, receptor-binding investigations and neuroleptic SAR research. Also valuable in exploring multi-receptor CNS drug interactions.
Side Effects and Risks
Risks include extrapyramidal symptoms, tardive dyskinesia, sedation, hypotension, anticholinergic effects, neuroleptic malignant syndrome, hyperprolactinemia and QT prolongation. Handle with CNS-active neuroleptic precautions.
Datasheet
| Molecular Formula | C17H20Cl2N2S |
|---|---|
| Molecular Weight | 355.3 g/mol |
| CAS Number | 69-09-0 |
| Storage Condition | Chlorpromazine hydrochloride oral solutions, tablets, and injection should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing of the oral solutions and injection should be avoided. … Chlorpromazine suppositories should be stored in well-closed containers between 15-30 °C. …Chlorpromazine hydrochloride oral concentrate solution should be dispensed in amber glass bottles. |
| Solubility | greater than or equal to 100 mg/mL at 75 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Chlorpromazine hydrochloride; 69-09-0; Chlorpromazine Hcl; Sonazine; Chloractil |
| IUPAC/Chemical Name | 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride |
| InChl Key | FBSMERQALIEGJT-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H |
| References |
3D Conformer.
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