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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Chlorosal (salicylanilide derivative) is an antimicrobial agent that disrupts bacterial oxidative phosphorylation. By uncoupling electron-transport chains, it collapses proton gradients across microbial membranes, inhibiting ATP synthesis and causing cell death. It shows strong activity against gram-positive bacteria and some fungi.
Benefits and Advantages
Used in mitochondrial‑uncoupling research, antimicrobial‑resistance modelling, oxidative‑stress assays, membrane‑potential measurements and salicylanilide SAR investigations.
Side Effects and Risks
Risks include dermal irritation, hepatotoxicity at systemic exposure, mitochondrial toxicity in mammalian cells and environmental persistence. Handle with uncoupler‑class compound precautions.
Datasheet
| Molecular Formula | C7H6ClN3O4S2 |
|---|---|
| Molecular Weight | 295.7 g/mol |
| CAS Number | 58-94-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 67.1 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | chlorothiazide; 58-94-6; Diuril; Chlorthiazide; Chlorothiazid |
| IUPAC/Chemical Name | 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide |
| InChl Key | JBMKAUGHUNFTOL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) |
| References |
3D Conformer.
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