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Product Description
Mechanism of Action
Chloroquine is a 4‑aminoquinoline compound that accumulates in parasite food vacuoles, raising vacuolar pH and inhibiting heme‑polymerisation. Free heme becomes toxic, causing oxidative damage and parasite death. Chloroquine also modulates autophagy, lysosomal pH, and toll‑like receptor signalling in mammalian cells.
Benefits and Advantages
Used in malaria‑biology research, lysosomal‑pH modulation studies, autophagy inhibition assays, antiviral pathway research, and toll‑like receptor signalling investigations. A reference compound for endosomal‑acidification studies.
Side Effects and Risks
Risks include retinopathy, QT prolongation, neurotoxicity, hypoglycaemia, GI upset and dermatologic reactions. Handle as a high-potency lysosomotropic agent.
Datasheet
| Molecular Formula | C18H26ClN3 |
|---|---|
| Molecular Weight | 319.9 g/mol |
| CAS Number | 54-05-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Bitter colorless crystals, dimorphic. Freely soluble in water, less sol in neutral or alkaline pH. Stable to heat in soln pH4 to 6.5. Practically in soluble in alcohol, benzene and chloroform /Diphosphate/ |
| Purity | Purity information is available upon request (COA). |
| Synonym | chloroquine; 54-05-7; Aralen; Chloraquine; Chlorochin |
| IUPAC/Chemical Name | 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine |
| InChl Key | WHTVZRBIWZFKQO-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) |
| References |
3D Conformer.
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