CELECOXIB
Celecoxib is a COX2 inhibitor reducing pain and inflammation with lower GI risk than NSAIDs. Side effects include cardiovascular risk, edema, and dyspepsia. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Celecoxib is a selective cyclooxygenase2 (COX2) inhibitor that reduces synthesis of proinflammatory prostaglandins while sparing COX1mediated gastric protection and platelet aggregation. It reduces inflammation, pain signalling and vascular prostaglandindriven responses through reversible COX2 blockade and downstream reduction of prostaglandin E.
Benefits and Advantages
Used in inflammatorypathway research, COX2 selectivity modelling, prostaglandin synthesis studies, tumourmicroenvironment investigations, painmodulation assays and NSAID SAR profiling. Also applied in angiogenesisinhibition and cytokineregulation research.
Side Effects and Risks
Risks include cardiovascular events, renal impairment, fluid retention, GI irritation (reduced vs nonselective NSAIDs), and rare hypersensitivity. Handle with NSAIDclass precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C17H14F3N3O2S |
|---|---|
| Molecular Weight | 381.4 g/mol |
| CAS Number | 169590-42-5 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | Poorly soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | celecoxib; 169590-42-5; Celebrex; Celebra; Onsenal |
| IUPAC/Chemical Name | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide |
| InChl Key | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) |
| References |
3D Conformer.
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