About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Cefotaxime is a thirdgeneration cephalosporin known for strong gramnegative activity and good CNS penetration. It binds multiple PBPs in Enterobacteriaceae and inhibits cell-wall synthesis. Its active metabolite, desacetylcefotaxime, also possesses antimicrobial activity. It is a cornerstone molecule in meningitis research due to effective CSF penetration.
Benefits and advantages
Used in CNS infection modelling, PBPs binding studies, ESBL-producing organism research, neonatal sepsis models, lactamase-resistance investigations and advanced cephalosporin SAR profiling.
Side effects and risks
Risks include hypersensitivity, GI symptoms, risk of C. difficile overgrowth, hepatic disturbances and rare neutropenia. Handle with antimicrobial precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C16H17N5O7S2 |
|---|---|
| Molecular Weight | 455.5 g/mol |
| CAS Number | 63527-52-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | cefotaxime; 63527-52-6; Cephotaxime; Cefotaxima; Cefotaximum |
| IUPAC/Chemical Name | (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| InChl Key | GPRBEKHLDVQUJE-QSWIMTSFSA-N |
| InChl Code | InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1 |
| References |
3D Conformer.
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