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Product Description
Mechanism of action
Ceforanide is a second‑generation cephalosporin with enhanced stability against β‑lactamases and a prolonged plasma half‑life. It inhibits PBPs and blocks crosslinking of peptidoglycan strands, impairing structural integrity of bacterial cell walls. Its extended half‑life enables less frequent dosing in experimental models.
Benefits and advantages
Used in PK/PD modelling of long‑acting cephalosporins, gram‑positive pathogen studies, β‑lactamase‑resistance screening, bone/joint infection models, and cephalosporin SAR research.
Side effects and risks
Risks include hypersensitivity, GI upset, hepatic enzyme changes and occasional nephrotoxicity. Handle using β‑lactam safety protocols.
Datasheet
| Molecular Formula | C20H18N8O6S2 |
|---|---|
| Molecular Weight | 519.6 g/mol |
| CAS Number | 60925-61-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 1.97e-01 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | CEFORANIDE; 60925-61-3; Precef; Ceforanido; Ceforanidum |
| IUPAC/Chemical Name | (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[1-(carboxymethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| InChl Key | SLAYUXIURFNXPG-CRAIPNDOSA-N |
| InChl Code | InChI=1S/C20H21N7O6S2/c21-6-11-4-2-1-3-10(11)5-13(28)22-15-17(31)27-16(19(32)33)12(8-34-18(15)27)9-35-20-23-24-25-26(20)7-14(29)30/h1-4,15,18H,5-9,21H2,(H,22,28)(H,29,30)(H,32,33)/t15-,18-/m1/s1 |
| References |
3D Conformer.
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