About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Camptothecin is a plant-derived alkaloid that selectively inhibits topoisomerase I, an enzyme essential for relieving torsional strain during DNA replication. By stabilising the topoisomerase IDNA cleavage complex, camptothecin prevents re-ligation of single-strand breaks, leading to replication fork collapse, double-strand breaks and apoptosis.
Benefits and advantages
Used in oncology research, DNA-repair pathway studies, topoisomerase-inhibitor SAR profiling, cell-cycle checkpoint modelling, drug-resistance analysis and replication-stress investigations. It is a foundational compound for modern camptothecin analogues such as irinotecan and topotecan.
Side effects and risks
Risks include severe myelosuppression, diarrhoea, mucositis, hepatotoxicity, photosensitivity and cytotoxicity. Handle with full cytotoxic-agent containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C20H16N2O4 |
|---|---|
| Molecular Weight | 348.4 g/mol |
| CAS Number | 2114454 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | camptothecin; 7689-03-4; Camptothecine; (S)-(+)-Camptothecin; (+)-Camptothecin |
| IUPAC/Chemical Name | (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione |
| InChl Key | VSJKWCGYPAHWDS-FQEVSTJZSA-N |
| InChl Code | InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1 |
| References |
3D Conformer.
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