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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Butenafine is a benzylamine antifungal that inhibits squalene epoxidase, blocking ergosterol biosynthesis and causing toxic accumulation of squalene within fungal cells. This disrupts membrane structure and function, leading to fungal cell death. It is active against dermatophytes, yeasts and moulds.
Benefits and advantages
Used in antifungal mechanism studies, ergosterol-pathway research, dermatophyte susceptibility testing, benzylamine SAR investigation and topical-formulation development.
Side effects and risks
Risks include skin irritation, erythema, itching and rare allergic reactions. Handle as an antifungal API with dermal-protection PPE.
Datasheet
| Molecular Formula | C23H28ClN |
|---|---|
| Molecular Weight | 353.9 g/mol |
| CAS Number | 101827-46-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Slightly soluble (HCl salt) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Butenafine hydrochloride; 101827-46-7; Butenafine HCL; Mentax; KP-363 |
| IUPAC/Chemical Name | 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride |
| InChl Key | LJBSAUIFGPSHCN-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H |
| References |
3D Conformer.
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