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Product Description
Mechanism of action
Buquinolate is a quinoline-derived antiprotozoal compound that disrupts mitochondrial electron transport in susceptible parasites. Its mechanism involves inhibition of electron flow at the cytochrome bc₁ complex, impairing oxidative phosphorylation and collapsing ATP production. This leads to parasite energy failure, membrane depolarisation, and eventual cell death. The compound may also exert secondary effects on folate-linked metabolic pathways often coupled to mitochondrial respiration in protozoa.
Benefits and advantages
Used in protozoal energy-metabolism research, mitochondrial electron-transport chain modelling, antimalarial and anticoccidial drug-development programmes, quinoline SAR studies and resistance-mechanism evaluations. Its defined mitochondrial target offers a clean system for studying bioenergetic collapse in parasites.
Side effects and risks
Risks include hepatic stress, mitochondrial toxicity at high doses, hypersensitivity and environmental persistence typical of some quinoline derivatives. Handle with antimicrobial and quinoline-compound precautions.
Datasheet
| Molecular Formula | C20H27NO5 |
|---|---|
| Molecular Weight | 361.4 g/mol |
| CAS Number | 1309823 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | BUQUINOLATE; 5486-03-3; Buquinolato; EU-1093; Buquinolatum |
| IUPAC/Chemical Name | ethyl 6,7-bis(2-methylpropoxy)-4-oxo-1H-quinoline-3-carboxylate |
| InChl Key | LVVXOXRUTDAKFE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H27NO5/c1-6-24-20(23)15-9-21-16-8-18(26-11-13(4)5)17(25-10-12(2)3)7-14(16)19(15)22/h7-9,12-13H,6,10-11H2,1-5H3,(H,21,22) |
| References |
3D Conformer.
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