About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Product Description
Mechanism of action
Bupropion is a norepinephrine–dopamine reuptake inhibitor (NDRI) that increases synaptic NE and DA by blocking their respective transporters. It also acts as a non-competitive nicotinic acetylcholine receptor antagonist, contributing to anti-addictive properties. Its stimulant-like profile contrasts with traditional antidepressants.
Benefits and advantages
Used in depression research, addiction-modelling studies (particularly nicotine dependence), neurochemical transport studies, dopaminergic–noradrenergic pathway analysis and receptor-occupancy modelling.
Side effects and risks
Risks include insomnia, hypertension, anxiety, seizure risk (dose-dependent), dry mouth and agitation. Handle as a CNS-stimulant and transporter-modulating compound.
Datasheet
| Molecular Formula | C13H19ClNO |
|---|---|
| Molecular Weight | 276.20 g/mol |
| CAS Number | 31677-93-7 |
| Storage Condition | Conventional tablets of bupropion hydrochloride should be stored at a temperature of 15-25 °C and protected from light and moisture.1 Extended-release, film-coated tablets of bupropion hydrochloride (e.g., Wellbutrin SR, Zyban) should be stored in tight, light-resistant containers at a temperature of 20-25 °C.142 143 Wellbutrin XL extended-release tablets should be stored at a temperature of 25 °C, but may be exposed to temperatures ranging from 15-30 °C. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Bupropion hydrochloride; 31677-93-7; Bupropion Hcl; Amfebutamone hydrochloride; Wellbutrin XL |
| IUPAC/Chemical Name | 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrochloride |
| InChl Key | HEYVINCGKDONRU-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H |
| References |
3D Conformer.
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