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Product Description
Mechanism of action
Buflomedil is a vasoactive peripheral vasodilator that improves microcirculation by blocking α₁-adrenergic receptors and inhibiting phosphodiesterase activity, leading to increased intracellular cAMP and relaxation of vascular smooth muscle. It also enhances red blood cell deformability and reduces platelet aggregation, improving tissue perfusion especially in ischemic environments.
Benefits and advantages
Used in microcirculation research, peripheral arterial disease models, endothelial-function studies, hemorheology investigations, vasodilator SAR profiling and platelet–vascular interaction research. It is also valuable for studying impaired oxygen delivery in peripheral vascular disorders.
Side effects and risks
Risks include neurotoxicity at high doses, seizures, hypotension, cardiac arrhythmias and GI disturbance. Handle with caution under cardiovascular-active compound safety protocols.
Datasheet
| Molecular Formula | C17H25NO4 |
|---|---|
| Molecular Weight | 307.4 g/mol |
| CAS Number | 55837-25-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Buflomedil; 55837-25-7; Buflomedilum; 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone; V7I71DQ432 |
| IUPAC/Chemical Name | 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one |
| InChl Key | OWYLAEYXIQKAOL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3 |
| References |
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