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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of action
Bromazinum is an antihistaminic and sedative agent structurally related to classical H₁‑antihistamines. It blocks H₁‑receptors, reducing histamine‑mediated vasodilation, vascular permeability and sensory‑nerve activation. It also has central sedative properties attributed to mild anticholinergic and sodium‑channel–modulating effects.
Benefits and advantages
Used in allergy‑mechanism studies, histamine‑receptor pharmacology, pruritus models, antihistamine SAR analysis, and research involving sedative–anticholinergic interactions. Helpful for mapping peripheral vs central H₁‑receptor actions.
Side effects and risks
Risks include sedation, anticholinergic effects (dry mouth, blurred vision), dizziness, GI upset and rare hypersensitivity. Handle under CNS‑active–compound precautions.
Datasheet
| Molecular Formula | C17H20BrNO |
|---|---|
| Molecular Weight | 334.2 g/mol |
| CAS Number | 118-23-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 3.45e-03 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | Bromazine; bromodiphenhydramine; Bromdiphenhydramine; Histabromamine; 118-23-0 |
| IUPAC/Chemical Name | 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine |
| InChl Key | NUNIWXHYABYXKF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 |
| References |
3D Conformer.
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