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Product Description
Mechanism of action
Benzbromarone is a potent uricosuric agent that selectively inhibits URAT1 (SLC22A12) in the renal proximal tubule, preventing uric acid reabsorption. It also inhibits GLUT9 and OAT4, reinforcing its strong urate-lowering effect. Additionally, benzbromarone modulates hepatic cytochrome enzymes and appears to demonstrate antioxidant effects in vitro by scavenging reactive oxygen species.
Benefits and advantages
Benzbromarone is widely used as a reference compound in urate transporter research, gout drug development, renal physiology models and pharmacogenomic studies examining URAT1 variants. Its high potency provides clear insights into tubular urate transport, making it crucial for transporter-kinetic studies.
Side effects and risks
Risks include severe hepatotoxicity, hypersensitivity reactions and endocrine modulation. Laboratory use requires controlled handling and protection from ingestion or dermal exposure.
Datasheet
| Molecular Formula | C17H12Br2O3 |
|---|---|
| Molecular Weight | 424.1 g/mol |
| CAS Number | 3562-84-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | benzbromarone; 3562-84-3; Benzbromaron; Uroleap; MJ 10061 |
| IUPAC/Chemical Name | (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone |
| InChl Key | WHQCHUCQKNIQEC-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3 |
| References |
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