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Product Description
Mechanism of action
Benzarone is a uricosuric and vasodilatory agent known for inhibiting hepatic uptake and tubular reabsorption of uric acid, thereby increasing renal uric acid excretion. Mechanistically, benzarone interferes with organic anion transporters involved in urate handling and exhibits mild xanthine oxidase–modulating properties. Additionally, benzarone displays microcirculatory benefits by reducing blood viscosity and promoting peripheral vasodilation, partly through endothelium-dependent mechanisms and inhibition of platelet aggregation.
Benefits and advantages
Benzarone is used in research exploring uric acid metabolism, gout pharmacotherapy development, microvascular perfusion modelling and endothelial-function pathways. It serves as a comparative compound in studies profiling uricosurics and evaluating renal transporter responsiveness. Its dual action on urate excretion and peripheral circulation provides utility in combined metabolic–vascular models.
Side effects and risks
Risks include hepatotoxicity, hypersensitivity reactions, gastric irritation and elevated liver enzymes. Strict handling with chemical- safety PPE and avoidance of inhalation or prolonged exposure is required.
Datasheet
| Molecular Formula | C17H14O3 |
|---|---|
| Molecular Weight | 266.29 g/mol |
| CAS Number | 1477-19-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Benzarone; 1477-19-6; (2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone; Benzaron; Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxyphenyl)- |
| IUPAC/Chemical Name | (2-ethyl-1-benzofuran-3-yl)-(4-hydroxyphenyl)methanone |
| InChl Key | RFRXIWQYSOIBDI-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3 |
| References |
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