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Product Description
Mechanism of action
Bendamustine hydrochloride is a bifunctional alkylating agent combining a nitrogen mustard moiety with a benzimidazole ring. It forms inter‑ and intrastrand DNA crosslinks, inducing apoptosis in rapidly proliferating cells. Bendamustine also triggers DNA‑damage responses, mitotic arrest and mitochondrial‑mediated cell death.
Benefits and advantages
Crucial in cancer research including lymphoma, chronic lymphocytic leukaemia and solid‑tumour models. Used to study alkylator‑resistance mechanisms, DNA repair pathways, apoptosis signalling, and structure‑activity relationships among nitrogen mustards.
Side effects and risks
Risks include severe myelosuppression, nausea, mucositis, hepatotoxicity, infusion reactions and secondary malignancy risk. Requires full cytotoxic‑handling containment, closed systems and PPE.
Datasheet
| Molecular Formula | C16H22Cl2N2O2·HCl |
|---|---|
| Molecular Weight | 394.7 g/mol |
| CAS Number | 3543-75-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >63.7 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Bendamustine hydrochloride; 3543-75-7; Bendamustine HCl; Treanda; Ribomustin |
| IUPAC/Chemical Name | 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydrochloride |
| InChl Key | ZHSKUOZOLHMKEA-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H |
| References |
3D Conformer.
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