About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Bacitracin is a cyclic polypeptide antibiotic that inhibits bacterial cellwall synthesis by interfering with the dephosphorylation of bactoprenol pyrophosphate, a lipid carrier responsible for shuttling peptidoglycan precursors across the cytoplasmic membrane. By preventing regeneration of the bactoprenol carrier, bacitracin effectively halts polymerisation of the cell wall. The compound exhibits strong activity against Grampositive organisms.
Benefits and advantages
Widely used in cellwall biosynthesis research, membrane transport studies, peptidoglycan precursor trafficking models and investigations into lipidcycle antibiotics. Its mechanism provides key insights into carrierlipid biochemistry.
Side effects and risks
Bacitracin may cause nephrotoxicity, allergic dermatitis and local irritation. In concentrated form, it requires biologicalagent containment and careful dermal protection.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C66H103N17O16S |
|---|---|
| Molecular Weight | 1422.7 g/mol |
| CAS Number | 1405-87-4 |
| Storage Condition | Bacitracin ophthalmic ointment should be stored at 15-30 °C. |
| Solubility | Freely soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | Fortracin; Bacitracina; Bacitracine; Bacitracinum; Parentracin |
| IUPAC/Chemical Name | (4R)-4-[[(2S)-2-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
| InChl Key | CLKOFPXJLQSYAH-ABRJDSQDSA-N |
| InChl Code | InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54-/m0/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
