About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Aztreonam is a monobactam lactam antibiotic that selectively binds to penicillinbinding protein 3 (PBP3) in Gramnegative bacteria. Inhibition of PBP3 disrupts the terminal stages of peptidoglycan crosslinking, producing defective bacterial cell division and leading to filamentation and lysis. Aztreonam is highly stable against most serine lactamases and demonstrates potent activity against Enterobacteriaceae and *Pseudomonas aeruginosa*.
Benefits and advantages
Extensively used in microbiology research focused on Gramnegative cellwall biology, lactam resistance mechanisms, PBP targetmapping, and synergy studies with lactamase inhibitors. Its monobactam structure allows clear mechanistic differentiation from penicillins and cephalosporins.
Side effects and risks
Potential risks include rash, hepatic enzyme elevations, GI disturbances and rare hypersensitivity (though cross reactivity with penicillins is minimal). Must be handled under antimicrobial API safety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C13H17N5O8S2 |
|---|---|
| Molecular Weight | 435.4 g/mol |
| CAS Number | 78110-38-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Insoluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | aztreonam; Azactam; 78110-38-0; Primbactam; Azthreonam |
| IUPAC/Chemical Name | 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid |
| InChl Key | WZPBZJONDBGPKJ-VEHQQRBSSA-N |
| InChl Code | InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1 |
| References |
3D Conformer.
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