About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Azacytidine (5‑azacytidine) is a ribonucleoside analogue that incorporates into RNA and DNA. In DNA, it forms a covalent bond with DNA methyltransferases (DNMTs), inhibiting methylation and promoting hypomethylation of CpG sites. This reactivates silenced tumour‑suppressor genes and disrupts malignant epigenetic patterns. In RNA, azacytidine alters tRNA processing and protein translation.
Benefits and advantages
A cornerstone in epigenetics research, cancer biology, myelodysplastic syndrome models, DNA methylation mapping, and chromatin‑regulation studies. Used to investigate methylome reprogramming and differentiation signalling.
Side effects and risks
Severe myelosuppression, GI toxicity, hepatic injury and mutagenicity. Requires cytotoxic‑grade safety cabinets and closed‑transfer systems.
Datasheet
| Molecular Formula | C8H12N4O5 |
|---|---|
| Molecular Weight | 244.20 g/mol |
| CAS Number | 320-67-2 |
| Storage Condition | Intact vials should be stored under refrigeration & are stable for a least 4 yr. Although the drug is stable for 3 yr at room temp, refrigeration is recommended because degradation may result at elevated temperatures. The constituted soln hydrolyzes at room temp & should be used within 30 min. … Azacitidine 0.5 & 2 mg/ml in Ringer's injection, lactated, was stable for up to one month when frozen at -20 °C in polypropylene syringes. |
| Solubility | 5 to 10 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | 5-azacytidine; Azacitidine; 320-67-2; Azacytidine; Ladakamycin |
| IUPAC/Chemical Name | 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one |
| InChl Key | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
| InChl Code | InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 |
| References |
3D Conformer.
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