About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Atenolol is a cardioselective -adrenergic receptor antagonist. It preferentially blocks receptors in cardiac tissue, leading to decreased heart rate (negative chronotropy), reduced myocardial contractility (negative inotropy) and reduced renin secretion from juxtaglomerular cells. These effects result in lowered blood pressure and diminished myocardial oxygen demand, with reduced bronchial blockade compared with non-selective beta-blockers.
Benefits and advantages
In cardiovascular research, atenolol is a standard reference compound for exploring -selective blockade, baroreflex physiology, sympathetic modulation and comparative beta-blocker pharmacodynamics. It is also useful in modelling reninangiotensin system interactions and heart-rate control in exercise or stress protocols.
Side effects and risks
Risks include bradycardia, atrioventricular conduction disturbances, hypotension, fatigue, cold extremities and, in susceptible patients, worsening heart failure. Abrupt withdrawal can provoke rebound tachycardia or angina. Laboratory handling should minimise dust generation and exposure due to its potent cardiovascular activity.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C14H22N2O3 |
|---|---|
| Molecular Weight | 266.34 g/mol |
| CAS Number | 29122-68-7 |
| Storage Condition | Atenolol tablets … should be protected from heat, light, and moisture and stored in well closed, light-resistent containers at 20-30 °C. Atenolol injection should be stored at room temperature between 20-25 °C and protected from light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | atenolol; 29122-68-7; Tenormin; Prenormine; Myocord |
| IUPAC/Chemical Name | 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide |
| InChl Key | METKIMKYRPQLGS-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18) |
| References |
3D Conformer.
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