ANSACRINE
Ansacrine is an acridine derivative with antineoplastic potential through DNA intercalation and topoisomerase inhibition. Benefits include experimental anticancer activity. Side effects may involve GI upset, bone marrow suppression, and cardiotoxicity. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Ansacrine is an acridine analog related to amsacrine, functioning as a DNA intercalator and topoisomerase II inhibitor. It stabilizes the cleavable topoisomeraseDNA complex, causing replication fork collapse and DNA doublestrand breaks.
Benefits and advantages
Useful in oncopharmacology for evaluating DNA intercalation, cytotoxic structureactivity relationships, apoptotic induction pathways, and topoisomeraserelated drug resistance mechanisms.
Side effects and risks
Has cytotoxic properties including myelosuppression, mucositis, and cardiotoxicity. Requires cytotoxicgrade laboratory management.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H19N3O3S |
|---|---|
| Molecular Weight | 393.5 g/mol |
| CAS Number | 51264-14-3 |
| Storage Condition | PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for … expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties …) that bears appropriate label. An inventory … should be kept, showing quantity of carcinogen & date it was acquired … Facilities for dispensing … should be contiguous to storage area. /Chemical Carcinogens/ |
| Solubility | <1 mg/mL |
| Purity | Purity information is available upon request (COA). |
| Synonym | amsacrine; 51264-14-3; Amsidine; m-AMSA; Amsidyl |
| IUPAC/Chemical Name | 1-nitro-9-(dimethylamino)acridin-2-one |
| InChl Key | SFYOLIDFNVWQSK-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23) |
| References |
3D Conformer.
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