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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of action
Amlodipine is a dihydropyridine-type L‑type calcium channel blocker that preferentially inhibits voltage-dependent Ca²⁺ influx in arterial vascular smooth muscle. The reduction in intracellular calcium prevents actin–myosin cross-bridge formation, resulting in vasodilation and reduced systemic vascular resistance. Due to slow receptor association/dissociation kinetics, amlodipine produces sustained 24‑hour antihypertensive effects with minimal reflex tachycardia.
Benefits and advantages
Amlodipine is essential in cardiovascular pharmacology, haemodynamics modelling and studies involving endothelial shear stress and nitric oxide signalling. Its long half-life and clean pharmacokinetic profile make it a preferred reference compound for evaluating new vasoactive agents.
Side effects and risks
Peripheral oedema, flushing, fatigue and gingival hyperplasia are common. Rare but serious reactions include hypotension and hepatic enzyme elevation. Proper PPE is required due to vasodilatory potency.
Datasheet
| Molecular Formula | C20H25ClN2O5 |
|---|---|
| Molecular Weight | 408.9 g/mol |
| CAS Number | 88150-42-9 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. /Amlodipine besylate/ |
| Solubility | slightly soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | amlodipine; 88150-42-9; Amlodipino; Amlodipinum; Amlodipine Free Base |
| IUPAC/Chemical Name | 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate |
| InChl Key | HTIQEAQVCYTUBX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 |
| References |
3D Conformer.
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