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Product Description
Mechanism of action
Alufibrate is a fibrate-class lipid-modifying agent thought to act as an agonist of peroxisome proliferator-activated receptor alpha (PPAR-α). Activation of this nuclear receptor upregulates genes involved in fatty acid oxidation and lipoprotein metabolism, leading to decreased hepatic production of very-low-density lipoproteins (VLDL) and increased clearance of triglyceride-rich particles.
Benefits and advantages
Like other fibrates, alufibrate is intended for the management of hypertriglyceridaemia and mixed dyslipidaemia, particularly in patients with elevated triglycerides and low HDL cholesterol. By improving the lipid profile, fibrates can contribute to cardiovascular risk reduction when used in conjunction with diet and lifestyle interventions.
Side effects and risks
Adverse effects associated with fibrates include dyspepsia, elevated liver enzymes, gallstone formation and, in rare cases, myopathy or rhabdomyolysis, especially when combined with statins. Renal impairment increases exposure and risk, necessitating dose adjustment in clinical products. In raw-material form, alufibrate should be managed with appropriate occupational safety measures.
Datasheet
| Molecular Formula | C20H21AlCl2O7 |
|---|---|
| Molecular Weight | 471.3 g/mol |
| CAS Number | 14613-01-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Aluminum clofibrate; Clofibrate d'aluminium; Clofibrato de aluminio; Clofibric acid basic aluminum salt; 56203T2K2X |
| IUPAC/Chemical Name | aluminum;bis(2-(4-chlorophenoxy)-2-methylpropanoate);hydroxide |
| InChl Key | USWVMPGQVYZHCA-UHFFFAOYSA-K |
| InChl Code | InChI=1S/2C10H11ClO3.Al.H2O/c2*1-10(2,9(12)13)14-8-5-3-7(11)4-6-8;;/h2*3-6H,1-2H3,(H,12,13);;1H2/q;;+3;/p-3 |
| References |
3D Conformer.
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