ACTINOMYCIN D
Actinomycin D is an antitumor antibiotic that binds tightly to DNA at guaninecytosine-rich regions, blocking RNA polymerase and inhibiting transcription. It is widely used in oncology, including Wilms tumor and gestational trophoblastic disease. Benefits include strong cytostatic activity. Risks include myelosuppression, hepatotoxicity, mucositis, and gastrointestinal upset, requiring careful monitoring during therapy. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Actinomycin D (dactinomycin) is a polypeptide antibiotic with potent antineoplastic activity. It binds to doublestranded DNA at guaninecytosinerich regions, intercalating between base pairs and inhibiting RNA polymerasemediated transcription. This interference with nucleic acid synthesis leads to apoptosis of rapidly dividing cells.
Benefits and advantages
Actinomycin D is an established component of chemotherapy protocols for childhood malignancies such as Wilms tumour, rhabdomyosarcoma and certain gestational trophoblastic diseases. Its welldefined mechanism and long clinical experience make it an important reference compound in oncology.
Side effects and risks
Toxicities include severe myelosuppression, mucositis, gastrointestinal disturbances, alopecia and potential hepatotoxicity. Extravasation can cause intense local tissue necrosis. As a highly cytotoxic agent, it must be handled only under rigorous cytotoxicdrug safety procedures.
Professional use only. Supplied exclusively to licensed oncology centres and manufacturers.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C62H86N12O16 |
|---|---|
| Molecular Weight | 1255.4 g/mol |
| CAS Number | 50-76-0 |
| Storage Condition | Store at 25 °C (77deg F); excursions permitted to 15-30 °C (59-86 °F). Protect from light and humidity. |
| Solubility | Soluble at 50 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | DACTINOMYCIN; actinomycin D; Actinomycin C1; Cosmegen; Actinomycin IV |
| IUPAC/Chemical Name | 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide |
| InChl Key | RJURFGZVJUQBHK-IIXSONLDSA-N |
| InChl Code | InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1 |
| References |
3D Conformer.
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