ACETYLSULFISOXAZOLE
Acetylsulfisoxazole is a sulfonamide that blocks folate synthesis in bacteria. Used for UTIs and respiratory infections. Benefits include strong absorption and broad activity. Risks include hypersensitivity, GI irritation, crystalluria, and rare blood disorders. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Acetylsulfisoxazole is an acetylated sulfonamide antibacterial. After deacetylation in vivo it acts as a competitive inhibitor of dihydropteroate synthase in the folate synthesis pathway of susceptible bacteria, thereby inhibiting growth through impairment of nucleic acid synthesis.
Benefits and advantages
Sulfonamides have broad antibacterial activity and have historically been used for urinary and systemic infections. The acetylated derivative improves certain physicochemical properties, including solubility and tolerability, and can be incorporated into combination formulations.
Side effects and risks
Adverse reactions include hypersensitivity reactions (from mild rash to severe StevensJohnson syndrome), haematological disturbances, crystalluria and, rarely, hepatotoxicity. Crossreactivity with other sulfonamide drugs is possible. Use in humans requires careful risk assessment and monitoring; industrial handling must respect hazardoussubstance regulations.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C13H15N3O4S |
|---|---|
| Molecular Weight | 309.34 g/mol |
| CAS Number | 80-74-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Sulfisoxazole acetyl; 80-74-0; ACETYL SULFISOXAZOLE; Lipo Gantrisin; acetylsulfafurazole |
| IUPAC/Chemical Name | N-(4-aminophenyl)sulfonyl-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide |
| InChl Key | JFNWFXVFBDDWCX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H15N3O4S/c1-8-9(2)15-20-13(8)16(10(3)17)21(18,19)12-6-4-11(14)5-7-12/h4-7H,14H2,1-3H3 |
| References |
3D Conformer.
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