ACEMETACIN
Acemetacin is an NSAID that inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and providing analgesic and anti-inflammatory effects. It is used for arthritis and pain management. Benefits include strong efficacy and improved gastrointestinal tolerability compared to some NSAIDs. Risks include stomach irritation, dizziness, edema, and rare renal or cardiovascular complications. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Acemetacin is a nonsteroidal antiinflammatory drug (NSAID) and prodrug of indometacin. After administration it is rapidly deesterified to indometacin, which nonselectively inhibits cyclooxygenase (COX1 and COX2) and reduces the synthesis of prostaglandins involved in pain, inflammation and fever.
Benefits and advantages
Compared with indometacin itself, acemetacin may offer improved gastrointestinal tolerability while maintaining antiinflammatory and analgesic efficacy. It is used in rheumatic diseases, musculoskeletal disorders and other painful inflammatory conditions when formulated in appropriate dosage forms.
Side effects and risks
As with all NSAIDs, the main risks involve gastrointestinal irritation, ulceration and bleeding, renal impairment, fluid retention and potential cardiovascular events with longterm use. Hypersensitivity reactions, including bronchospasm in aspirinsensitive individuals, can occur. The API should be handled with care to avoid dust inhalation or skin contact, and finished medicinal products require careful patient selection and monitoring.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H18ClNO6 |
|---|---|
| Molecular Weight | 415.8 g/mol |
| CAS Number | 53164-05-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Slightly soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | acemetacin; 53164-05-9; Rantudil; Emflex; Acemix |
| IUPAC/Chemical Name | 2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid |
| InChl Key | FSQKKOOTNAMONP-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25) |
| References |
3D Conformer.
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